5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

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Chemical Name:5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester
CAS No.:1001608-59-8
Molecular Formula:C₂₃H₁₅FN₂O₂S
Molecular Weight:402.449
Hs Code.:

Synonyms:5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

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Chemical Property of 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

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Technology Process of 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

There total 8 articles about 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1001608-58-7
5-(2-chloro-quinolin-6-yl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

: 1993-03-9
o-fluorophenylboronic acid

: 1001608-59-8
5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 0.166667h; microwave reaction;

Reference yield:

: 1918-79-2
2-methylthiophene-5-carboxylic acid

: 1001608-59-8
5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; acetic anhydride / 0.17 h / -78 - 10 °C

2: sulfuric acid / 24 h / Heating / reflux

3: pyrrolidine / methanol / Heating / reflux

4: triethyl phosphite / 2 h / 160 °C / Heating / reflux

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 120 °C / microwave reaction

With potassium phosphate; sulfuric acid; nitric acid; acetic anhydride; triethyl phosphite; pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water;

Reference yield:

: 791626-59-0
2-chloroquinoline-6-carbaldehyde

: 1001608-59-8
5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyrrolidine / methanol / Heating / reflux

2: triethyl phosphite / 2 h / 160 °C / Heating / reflux

3: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 120 °C / microwave reaction

With potassium phosphate; triethyl phosphite; pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water;