Technology Process of 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester
There total 8 articles about 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 120 ℃;
for 0.166667h;
microwave reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: nitric acid; acetic anhydride / 0.17 h / -78 - 10 °C
2: sulfuric acid / 24 h / Heating / reflux
3: pyrrolidine / methanol / Heating / reflux
4: triethyl phosphite / 2 h / 160 °C / Heating / reflux
5: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.17 h / 120 °C / microwave reaction
With
potassium phosphate; sulfuric acid; nitric acid; acetic anhydride; triethyl phosphite;
pyrrolidine; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyrrolidine / methanol / Heating / reflux
2: triethyl phosphite / 2 h / 160 °C / Heating / reflux
3: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.17 h / 120 °C / microwave reaction
With
potassium phosphate; triethyl phosphite;
pyrrolidine; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; water;