(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide

Base Information

• Chemical Name: (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide
• CAS No.: 354157-91-8
• Molecular Formula: C₁₇H₁₂BrNO₃
• Molecular Weight: 358.191
• Mol file: 354157-91-8.mol

Synonyms:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide

Chemical Property of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide

There total 1 articles about (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-phthaloyl-L-phenylalanine (5123-55-7) → (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide (354157-91-8)

Guidance literature:

With 1-bromo-N,N,2-trimethyl-1-propen-1-amine; In dichloromethane; for 0.25h;

DOI:10.1016/S0040-4039(01)00584-6

Reference yield: 94.0%

3-phenyl-2-(trifluoromethyl-amino)-propionic acid ethyl ester + (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide (354157-91-8) → 2-{[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl]-trifluoromethyl-amino}-3-phenyl-propionic acid ethyl ester

Guidance literature:

With 2,3,5-trimethyl-pyridine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(01)00584-6

Reference yield: 83.0%

(S)-2-[2-(Difluoromethyl-amino)-3-phenyl-propionylamino]-propionic acid methyl ester + (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl bromide (354157-91-8) → (S)-2-(2-{Difluoromethyl-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionyl]-amino}-3-phenyl-propionylamino)-propionic acid methyl ester

Guidance literature:

With 2,3,5-trimethyl-pyridine; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1016/S0040-4039(01)00584-6

upstream raw materials:

Nα-phthaloyl-L-phenylalanine