tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate
• CAS No.: 1379575-70-8
• Molecular Formula: C₁₆H₂₃F₃N₂O₂
• Molecular Weight: 332.366
• Mol file: 1379575-70-8.mol

Synonyms:tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate

Chemical Property of tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate

There total 7 articles about tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-amine (459-00-7) + t-butyl 3-(trichloromethyl)-1,2-oxaziridine-2-carboxylate (219547-77-0) → tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate (1379575-70-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

1-(2-azido-2-methylpropyl)-4-(trifluoromethyl)benzene (1379575-71-9) → tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate (1379575-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium hydroxide, 20 wt% on carbon; hydrogen / ethyl acetate / 18 h / 20 °C

2: dichloromethane / 0.5 h / 20 °C / Cooling with ice

With palladium hydroxide, 20 wt% on carbon; hydrogen; In dichloromethane; ethyl acetate;

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) → tert-butyl 2-(2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazinecarboxylate (1379575-70-8)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether / 1 h / 20 °C / Cooling with ice

2: toluene / 4 h / 120 °C

3: potassium carbonate; Oxone / water; chloroform / 12 h / Cooling with ice

4: dichloromethane / 0.5 h / 20 °C / Cooling with ice

With Oxone; potassium carbonate; In diethyl ether; dichloromethane; chloroform; water; toluene;

upstream raw materials:

1-(2-azido-2-methylpropyl)-4-(trifluoromethyl)benzene

N-(tert-butyloxycarbonyl) azide

triphenyl(t-butoxycarbonylimino)phosphorane

2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-ol