6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

Base Information

Chemical Name:6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine
CAS No.:174148-74-4
Molecular Formula:C₄₁H₄₀N₄O₇
Molecular Weight:700.791
Hs Code.:

Synonyms:6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

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Chemical Property of 6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

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Technology Process of 6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

There total 7 articles about 6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 77-78-1
dimethyl sulfate

: 174291-06-6
6-N-<(benzyloxy)methyl>-3'-O-desmethyl-4'-N-desmethyl-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

: 174148-74-4
6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1021/ja952907g

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 174148-74-4
6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 30 min

2: 93 percent / Cs₂CO₃ / methanol / 0.75 h / Ambient temperature

3: 86 percent / NaH / tetrahydrofuran; dimethylformamide / 2 h / Ambient temperature

With sodium hydride; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja952907g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174148-74-4
6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / DMAP, Et₃N / tetrahydrofuran / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 30 min

3: 93 percent / Cs₂CO₃ / methanol / 0.75 h / Ambient temperature

4: 86 percent / NaH / tetrahydrofuran; dimethylformamide / 2 h / Ambient temperature

With dmap; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja952907g