N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

Base Information

Chemical Name:N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide
CAS No.:1389324-94-0
Molecular Formula:C₁₉H₂₀ClFN₂O₃S
Molecular Weight:410.897
Hs Code.:

Synonyms:N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

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Chemical Property of N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

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Technology Process of N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

There total 9 articles about N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389326-39-9
methyl 2-(4-chlorophenyl)-2-(6-fluoro-4-(methylsulfonamido)-1H-indol-1-yl)butanoate

: 1389324-94-0
N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

Guidance literature:: methyl 2-(4-chlorophenyl)-2-(6-fluoro-4-(methylsulfonamido)-1H-indol-1-yl)butanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 0.5h;

With hydrogenchloride; water; In tetrahydrofuran; pH=2 - 3; Cooling with ice;

Reference yield:

: 102735-88-6
5-fluoro-2-methyl-1,3-dinitrobenzene

: 1389324-94-0
N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: N,N-dimethyl-formamide / 5 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

3.1: sodium hydroxide / 3 h / 60 °C

4.1: tert-butyl alcohol / 16 h / 50 °C

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

5.2: 20 °C

6.1: sulfuric acid / 2 h / 50 °C

7.1: tert-butyl alcohol / 10 h / 50 °C

8.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1 h / -78 °C

8.2: 0.33 h / -20 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

10.1: 4-methyl-morpholine / dichloromethane / 1.5 h / 0 °C

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -78 °C

11.2: pH 2 - 3 / Cooling with ice

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; hydrogen; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 446-10-6
2-nitro-4-fluorotoluene

: 1389324-94-0
N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: nitric acid; sulfuric acid / 6 h / -5 - 20 °C

2.1: N,N-dimethyl-formamide / 5 h / 120 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4.1: sodium hydroxide / 3 h / 60 °C

5.1: tert-butyl alcohol / 16 h / 50 °C

6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

6.2: 20 °C

7.1: sulfuric acid / 2 h / 50 °C

8.1: tert-butyl alcohol / 10 h / 50 °C

9.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1 h / -78 °C

9.2: 0.33 h / -20 °C

10.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

11.1: 4-methyl-morpholine / dichloromethane / 1.5 h / 0 °C

12.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -78 °C

12.2: pH 2 - 3 / Cooling with ice

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; hydrogen; nitric acid; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;