N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine
• CAS No.: 1263870-52-5
• Molecular Formula: C₃₂H₃₂F₂N₈O
• Molecular Weight: 582.656
• Mol file: 1263870-52-5.mol

Synonyms:N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

Chemical Property of N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

There total 11 articles about N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-phenylamine (1185019-91-3) + 2-chloro-N-ethyl-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (1263870-46-7) → N4-ethyl-N2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-52-5)

Guidance literature:

With sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; at 110 ℃; for 24h; Inert atmosphere;

Reference yield:

4-fluorophenylacetonitrile (459-22-3) → N4-ethyl-N2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-52-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / -10 °C

1.2: -10 - 40 °C

1.3: 0 °C

2.1: sulfuric acid; hydrogen / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C / 3677.86 Torr

3.1: ethanol / 18 h / 20 °C

4.1: potassium carbonate / acetone / 3 h / Reflux

5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

6.1: potassium tert-butylate / ethanol / 24 h / Reflux

7.1: trichlorophosphate / N,N-dimethyl-formamide / 10 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 20 °C

9.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

With sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetic acid; acetone;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → N4-ethyl-N2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dimethyl sulfoxide / 48 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Cooling with ice-water

3: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

With hydrogen; sodium hydrogencarbonate; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; water; dimethyl sulfoxide;

upstream raw materials:

4-fluorophenylacetonitrile

3,4-difluoronitrobenzene

ethyl 2-cyano-2-(4-fluorophenyl)acetate

1-(2-Fluoro-4-nitro-phenyl)-5-methyl-1H-[1,2,4]triazole

Downstream raw materials:

N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine