1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine

Base Information

• Chemical Name: 1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine
• CAS No.: 134334-34-2
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.352
• Mol file: 134334-34-2.mol

Synonyms:1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine

Chemical Property of 1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine

There total 1 articles about 1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-5,5-(ethylenedioxy)-2-piperidinecarbonitrile (132462-23-8) → 1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine (134334-34-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.333333h; Yield given;

DOI:10.1021/jo00017a036

Reference yield: 82.0%

1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine (134334-34-2) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 7-benzyl-8-(2-nitrophenylaminomethyl)-1,4-dioxa-7-azaspiro<4.5>decane (139108-76-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield:

1-Benzyl-5-(ethylenedioxy)-2-piperidinemethanamine (134334-34-2) → 2-Benzylhexahydro-2H-pyrido<1,2-a>pyrazin-7(6H)-one (134334-40-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / CH₂Cl₂ / 0.25 h

2: Bu₄NBr / 1,2-dichloro-benzene / 1 h / Heating

3: LiAlH₄ / tetrahydrofuran / 3 h

4: Et₃N / CH₂Cl₂ / 1.) ice cooled, 1 h, 2.) r.t., 1 h

5: 92 percent / 6 M HCl / 3 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-benzene;

DOI:10.1021/jo00017a036

upstream raw materials:

1-Benzyl-5,5-(ethylenedioxy)-2-piperidinecarbonitrile

Downstream raw materials:

7-benzyl-8-(2-nitrophenylaminomethyl)-1,4-dioxa-7-azaspiro<4.5>decane

2-Benzylhexahydro-2H-pyrido<1,2-a>pyrazin-7(6H)-one

2-Benzyl-7-(ethylenedioxy)octahydro-2H-pyrido<1,2-a>-pyrazine