9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

Base Information

Chemical Name:9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine
CAS No.:75128-61-9
Molecular Formula:C₃₂H₃₉N₇O₄
Molecular Weight:585.706
Hs Code.:

Synonyms:9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

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Chemical Property of 9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

Chemical Property:

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Technology Process of 9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

There total 6 articles about 9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76066-17-6
(1RS)-2-amino-1-cyclopentylethanol hydrochloride

: 75128-61-9
9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / sodium acetate / acetic acid / 5 h / Heating

2: HCl / 1,2-dichloro-ethane / 3 h

3: 24 percent / Et₃N / dimethylformamide / 55 h

4: 2.) aq. methylamine / 1) 90 deg C, 18 h; 2) 90 deg C, 6.5 h

5: 1.) ethyl chloroformate, Et₃N, 2.) Et₃N / 1) THF, 0 - 5 deg C, 10 min; 2) CHCl₃, 1.5 h, room temperature

With hydrogenchloride; sodium acetate; chloroformic acid ethyl ester; triethylamine; methylamine; In acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600741211

Reference yield:

: 1-acetoxy-1-cyclopentylacetonitrile

: 75128-61-9
9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LiALH₄, 2.) HCl / 1) ether, 22 h, room temperature; 2) ethanol

2: 64 percent / sodium acetate / acetic acid / 5 h / Heating

3: HCl / 1,2-dichloro-ethane / 3 h

4: 24 percent / Et₃N / dimethylformamide / 55 h

5: 2.) aq. methylamine / 1) 90 deg C, 18 h; 2) 90 deg C, 6.5 h

6: 1.) ethyl chloroformate, Et₃N, 2.) Et₃N / 1) THF, 0 - 5 deg C, 10 min; 2) CHCl₃, 1.5 h, room temperature

With hydrogenchloride; lithium aluminium tetrahydride; sodium acetate; chloroformic acid ethyl ester; triethylamine; methylamine; In acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600741211

Reference yield:

: 100827-90-5
N-(2-cyclopentyl-2-hydroxyethyl)phthalimide

: 75128-61-9
9-(2-N-carbobenzoxyphenylalanylamido-1-cyclopentylethoxymethyl)-6-dimethylaminopurine

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / 1,2-dichloro-ethane / 3 h

2: 24 percent / Et₃N / dimethylformamide / 55 h

3: 2.) aq. methylamine / 1) 90 deg C, 18 h; 2) 90 deg C, 6.5 h

4: 1.) ethyl chloroformate, Et₃N, 2.) Et₃N / 1) THF, 0 - 5 deg C, 10 min; 2) CHCl₃, 1.5 h, room temperature

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; methylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600741211