3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Base Information

Chemical Name:3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester
CAS No.:1359823-59-8
Molecular Formula:C₂₈H₃₁F₄N₃O₈
Molecular Weight:613.563
Hs Code.:

Synonyms:3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Suppliers and Price of 3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

There total 11 articles about 3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1359823-58-7
3-{2-[((4-benzyloxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-59-8
3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

Reference yield:

: 315688-11-0
3-(2-amino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-59-8
3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 4 h / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 123-30-8
4-amino-phenol

: 1359823-59-8
3-{2-[(4-hydroxyphenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 73 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.2: pH 1

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 48 h / 20 °C / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 4 h / 20 °C

With 4-methyl-morpholine; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;