Technology Process of (17E)-1α-tert-butyldimethylsilyloxy-20-[3-(dimethylhydroxymethyl)phenyl]-17,20-didehydro-21,22,23,24,25,26,27-heptanorvitamin D3 tert-butyldimethylsilyl ether
There total 7 articles about (17E)-1α-tert-butyldimethylsilyloxy-20-[3-(dimethylhydroxymethyl)phenyl]-17,20-didehydro-21,22,23,24,25,26,27-heptanorvitamin D3 tert-butyldimethylsilyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 0.75h;
DOI:10.1021/jo000579j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 12 percent / KH / tetrahydrofuran / 4 h / Heating
2: 86 percent / Et3N; dppp / Pd(OAc)2 / dimethylsulfoxide / 12 h / 80 °C
3: 92 percent / aq. HF / acetonitrile / 3 h / 20 °C
4: 95 percent / PDC / CH2Cl2 / 8 h
5: 94 percent / n-BuLi / tetrahydrofuran; hexane / 6 h / -78 - -40 °C
6: 90 percent / tetrahydrofuran; diethyl ether / 0.75 h / -78 °C
With
dipyridinium dichromate; n-butyllithium; 1,3-bis-(diphenylphosphino)propane; hydrogen fluoride; potassium hydride; triethylamine;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; acetonitrile;
1: Condensation / 2: Addition / 3: Decomposition / 4: Oxidation / 5: Condensation / 6: Grignard reaction;
DOI:10.1021/jo000579j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 12 percent / KH / tetrahydrofuran / 4 h / Heating
2: 86 percent / Et3N; dppp / Pd(OAc)2 / dimethylsulfoxide / 12 h / 80 °C
3: 92 percent / aq. HF / acetonitrile / 3 h / 20 °C
4: 95 percent / PDC / CH2Cl2 / 8 h
5: 94 percent / n-BuLi / tetrahydrofuran; hexane / 6 h / -78 - -40 °C
6: 90 percent / tetrahydrofuran; diethyl ether / 0.75 h / -78 °C
With
dipyridinium dichromate; n-butyllithium; 1,3-bis-(diphenylphosphino)propane; hydrogen fluoride; potassium hydride; triethylamine;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; acetonitrile;
1: Condensation / 2: Addition / 3: Decomposition / 4: Oxidation / 5: Condensation / 6: Grignard reaction;
DOI:10.1021/jo000579j
