5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole

Base Information

Chemical Name:5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole
CAS No.:1097120-49-4
Molecular Formula:C₁₈H₁₄BrClN₆
Molecular Weight:429.706
Hs Code.:

Synonyms:5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole

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Chemical Property of 5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole

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Technology Process of 5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole

There total 2 articles about 5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1097120-79-0
3-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)propanenitrile

: 1097120-49-4
5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1097120-77-8
3-[1-(4-bromo-phenyl)-3-(4-chloro-phenyl)-1H-pyrazol-4-yl]-propionamide

: 1097120-49-4
5-(2-(1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl)ethyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 2 h / 15 °C

2: sodium azide; zinc dibromide / water; isopropyl alcohol / 15 h / 120 °C

With sodium azide; triethylamine; trifluoroacetic anhydride; zinc dibromide; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.1c00837