2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester

Base Information

• Chemical Name: 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester
• CAS No.: 244139-04-6
• Molecular Formula: C₂₀H₂₅NO₆
• Molecular Weight: 375.422
• Mol file: 244139-04-6.mol

Synonyms:2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester

Chemical Property of 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester

There total 3 articles about 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

3-(3,4-dimethoxyphenyl)-N,N-dimethyl-3-oxo-1-propanamine hydrochloride (23694-21-5) + Methyl (2Z)-3-amino-4,4-diethoxybut-2-enoate → 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester (244139-04-6)

Guidance literature:

In methanol; for 48h; Heating;

Reference yield:

Methyl 4,4-diethoxy-2-oxobutyrate (83821-64-1) → 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester (244139-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NH₃ / ethanol / 2 h / 0 °C

2: 48 percent / methanol / 48 h / Heating

With ammonia; In methanol; ethanol; 1: Substitution / 2: Cyclocondensation;

Reference yield:

Ethyl diethoxyacetate (6065-82-3) → 2-diethoxymethyl-6-(3,4-dimethoxy-phenyl)-nicotinic acid methyl ester (244139-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / Na / 11 h / 70 °C

2: 87 percent / NH₃ / ethanol / 2 h / 0 °C

3: 48 percent / methanol / 48 h / Heating

With ammonia; sodium; In methanol; ethanol; 1: Claisen condesation / 2: Substitution / 3: Cyclocondensation;

upstream raw materials:

3-(3,4-dimethoxyphenyl)-N,N-dimethyl-3-oxo-1-propanamine hydrochloride

Methyl 4,4-diethoxy-2-oxobutyrate

Ethyl diethoxyacetate