(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate
CAS No.:1221179-38-9
Molecular Formula:C₃₀H₃₃FN₄O₆
Molecular Weight:564.614
Hs Code.:

Synonyms:(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

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Chemical Property of (R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

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Technology Process of (R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

There total 9 articles about (R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221179-35-6
(R)-2-(4-fluoro-3-nitrophenyl)oxirane

: 1221179-37-8
tert-butyl 6-(2-(benzylamino)ethoxy)-3-methylindazole-1-carboxylate

: 1221179-38-9
(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

Guidance literature:: In isopropyl alcohol; Reflux;

Reference yield:

: 201286-99-9
3-methyl-1H-indazol-6-ol

: 1221179-38-9
(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: triethylamine / dmap / dichloromethane / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

5: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C

6: isopropyl alcohol / Reflux

With 1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 519158-44-2
1-benzyl-3-methyl-1H-indazol-6-ol

: 1221179-38-9
(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 60 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: triethylamine / dmap / dichloromethane / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

6: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C

7: isopropyl alcohol / Reflux

With 1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;