5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

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Chemical Name:5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid
CAS No.:1561811-30-0
Molecular Formula:C₁₉H₁₂F₃N₅O₃
Molecular Weight:415.331
Hs Code.:

Synonyms:5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

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Chemical Property of 5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

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Technology Process of 5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

There total 8 articles about 5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 24242-20-4,114849-40-0
5-amino-pyridine-2-carboxylic acid

: 1561810-14-7
2-chloro-4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazine

: 1561811-30-0
5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; for 17h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.055

Reference yield: 57.0%

: 1561811-30-0
5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; for 17h; Reflux;

Reference yield:

: 159326-66-6
N-amino-1H-pyrrole-2-carbonitrile

: 1561811-30-0
5-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / 20 °C

2.1: pyridine / 1,4-dioxane / 0.25 h

2.2: 1 h / Reflux

3.1: sodium ethanolate / ethanol / 2 h / Reflux

4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 24 h / 120 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide; water / 4 h / 80 °C / Inert atmosphere

6.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 17 h / Reflux; Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; water; sodium ethanolate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5.1: |Suzuki Coupling / 6.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.055