3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Base Information

Chemical Name:3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid
CAS No.:1025762-62-2
Molecular Formula:C₂₄H₂₁FN₂O₂
Molecular Weight:388.441
Hs Code.:

Synonyms:3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Suppliers and Price of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

There total 3 articles about 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025762-66-6
3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

: 352-34-1
4-fluoro-1-iodobenzene

: 1025762-62-2
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Guidance literature:: With potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 24h;
DOI:10.1016/j.bmcl.2013.06.089

Reference yield:

: C₂₁H₂₆N₂O₂Si

: 1025762-62-2
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; dimethyl sulfoxide / 12 h / 100 °C

2: copper(l) iodide; potassium phosphate / 1,4-dioxane / 24 h / 110 °C

With potassium phosphate; copper(l) iodide; sodium hydroxide; In 1,4-dioxane; methanol; dimethyl sulfoxide; 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.06.089

Reference yield:

: 1025762-64-4
(1H-indazol-5-yl)(phenyl)methanol

: 1025762-62-2
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride / dichloromethane / 12 h / 0 °C

2: sodium hydroxide / methanol; dimethyl sulfoxide / 12 h / 100 °C

3: copper(l) iodide; potassium phosphate / 1,4-dioxane / 24 h / 110 °C

With potassium phosphate; copper(l) iodide; titanium tetrachloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1: |Mukaiyama Aldol Addition / 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.06.089