(S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

Base Information

Chemical Name:(S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate
CAS No.:1384453-56-8
Molecular Formula:C₂₂H₂₆O₅
Molecular Weight:370.445
Hs Code.:

Synonyms:(S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

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Chemical Property of (S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

Chemical Property:

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Technology Process of (S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

There total 6 articles about (S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1384453-43-3
(S)-2-hydroxy-2-(3-hydroxyphenyl)butyl benzoate

: 1384453-56-8
(S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In ethanol; toluene; at 20 ℃;
DOI:10.1021/jm3004174

Reference yield:

: 7781-98-8
ethyl-3-hydroxybenzoate

: 1384453-56-8
(S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 4 h / 60 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

4.1: tetrahydrofuran; diethyl ether / 3.16 h / 0 - 20 °C

5.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 12 h / 0 - 20 °C

6.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

8.1: acetic acid; trifluoroacetic acid / water / 3 h / 50 °C

9.1: di-isopropyl azodicarboxylate; triphenylphosphine / ethanol; toluene / 20 °C

With di-isopropyl azodicarboxylate; AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 5.2: Wittig reaction / 9.1: Mitsunobu reaction;
DOI:10.1021/jm3004174

Reference yield:

: 81245-43-4
3-(methoxymethoxy)benzoic acid

: 1384453-56-8
(S)-2-hydroxy-2-(3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butyl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 3.16 h / 0 - 20 °C

3.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 12 h / 0 - 20 °C

4.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C

5.1: triethylamine / dichloromethane / 2 h / 20 °C

6.1: acetic acid; trifluoroacetic acid / water / 3 h / 50 °C

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / ethanol; toluene / 20 °C

With di-isopropyl azodicarboxylate; AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 3.2: Wittig reaction / 7.1: Mitsunobu reaction;
DOI:10.1021/jm3004174