Technology Process of C15H15N
There total 3 articles about C15H15N which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[2R,(S)S]-4-methyl-2-(prop-2-ynyl)-2-[2-(p-tolylsulfinyl)phenyl]pent-4-enenitrile;
With
tert.-butyl lithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran; hexane; water;
Inert atmosphere;
DOI:10.1021/jo3011039
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
1.2: 0.17 h / 20 °C / Inert atmosphere
2.1: 18-crown-6 ether; sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
3.2: Inert atmosphere
With
18-crown-6 ether; tert.-butyl lithium; sodium hexamethyldisilazane; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo3011039
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 18-crown-6 ether; sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
2.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: Inert atmosphere
With
18-crown-6 ether; tert.-butyl lithium; sodium hexamethyldisilazane;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo3011039
![[2R,(S)S]-4-methyl-2-(prop-2-ynyl)-2-[2-(p-tolylsulfinyl)phenyl]pent-4-enenitrile](/Databaselist/images/loading.webp)
