(R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

Base Information

Chemical Name:(R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid
CAS No.:1206514-92-2
Molecular Formula:C₂₄H₃₇N₂O₇P
Molecular Weight:496.541
Hs Code.:

Synonyms:(R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

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Chemical Property of (R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

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Technology Process of (R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

There total 4 articles about (R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.3%

: 1206514-91-1
1-(((((R)-1-benzyloxycarbonylamino)ethyl)(hydroxy)phosphoryl)methyl)cyclopentane carboxylic acid

: 69320-88-3
tert-Butyl 2-aminopropanoate hydrochloride

: 1206514-92-2
(R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 113592-76-0
methyl <1-(R)-<(benzyloxycarbonyl)amino>ethyl>phosphinate

: 1206514-92-2
(R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - -60 °C / Inert atmosphere

1.2: 4.25 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

With n-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1-((trifluoromethylsulfonyloxy)methyl)cyclopentanoic acid tert-butyl ester

: 1206514-92-2
(R)-1-(benzyloxycarbonylamino)ethyl-(((1-(S)-1-tert-butoxy-1-oxypropan-2-ylcarbamoyl)cyclopentyl)methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - -60 °C / Inert atmosphere

1.2: 4.25 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

With n-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;