2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane
• CAS No.: 1333480-33-3
• Molecular Formula: C₂₃H₂₂O₃
• Molecular Weight: 346.426
• Mol file: 1333480-33-3.mol

Synonyms:2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane

Chemical Property of 2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane

There total 2 articles about 2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-Anisaldehyde dimethyl acetal (2186-92-7) + 2,2-diphenyl-1,3-propanediol (5464-86-8) → 2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane (1333480-33-3)

Guidance literature:

With 10-camphorsufonic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ol202104c

Reference yield:

Diphenylacetaldehyde (947-91-1) → 2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane (1333480-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol; water / Reflux

2: 10-camphorsufonic acid / dichloromethane / 2 h / 0 °C

With 10-camphorsufonic acid; potassium carbonate; In ethanol; dichloromethane; water;

DOI:10.1021/ol202104c

Reference yield: 100.0%

2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane (1333480-33-3) → 3-((4-methoxybenzyl)oxy)-2,2,-diphenylpropan-1-ol (1333480-34-4)

Guidance literature:

2-(4-methoxyphenyl)-5,5-diphenyl-1,3-dioxane; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 - 20 ℃;

With rochelle salt; In hexane; dichloromethane;

DOI:10.1021/ol202104c

upstream raw materials:

Diphenylacetaldehyde

p-Anisaldehyde dimethyl acetal

2,2-diphenyl-1,3-propanediol

Downstream raw materials:

C₂₂H₂₄

3-((4-methoxybenzyl)oxy)-2,2,-diphenylpropanal

1,1-dibromo-4-((4-methoxybenzyl)oxy)-3,3-diphenylbut-1-ene

4-((4-methoxybenzyl)oxy)-3,3-diphenylbut-1-yne

Refernces