6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

Base Information

Chemical Name:6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine
CAS No.:509953-14-4
Molecular Formula:C₂₀H₂₀BrN₃O₅
Molecular Weight:462.3
Hs Code.:

Synonyms:6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

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Chemical Property of 6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

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Technology Process of 6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

There total 1 articles about 6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 5-methoxy-3-(4-methoxy-phenyl)-[1,2,4]triazine

: 509953-14-4
6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

Guidance literature:: 5-methoxy-3-(4-methoxy-phenyl)-[1,2,4]triazine; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexane; at -95 ℃; for 1h;

2-bromo-4,5-dimethoxybenzaldehyde; In tetrahydrofuran; hexane; at -95 ℃; for 1h;
DOI:10.1055/s-2002-35630

Reference yield: 83.0%

: 509953-14-4
6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

: 509953-18-8
6-(2-bromo-3,4-dimethoxybenzoyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1055/s-2002-35630

Reference yield:

: 509953-14-4
6-(2-bromo-3,4-dimethoxy-α-hydroxybenzyl)-5-methoxy-3-(4-methoxyphenyl)-1,2,4-triazine

: 1,6,7-trimethoxy-4-[(dimethylamino)methyl]-3-(4-methoxyphenyl)-2-azafluorenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 83 percent / MnO₂ / tetrahydrofuran / 5 h / 20 °C

2.1: Pr₃N; CuI / PdCl₂(Ph₃P)2 / dimethylformamide / 0.33 h / 20 °C

2.2: dimethylformamide

3.1: 74 mg / 1.5 h / 100 - 120 °C

With tri-n-propylamine; manganese(IV) oxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 2.2: Sonogashira reaction / 3.1: intramolecular Diels-Alder reaction;
DOI:10.1055/s-2002-35630