(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

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Chemical Name:(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran
CAS No.:854931-17-2
Molecular Formula:C₃₀H₄₀O₅
Molecular Weight:480.645
Hs Code.:

Synonyms:(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

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Chemical Property of (S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

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Technology Process of (S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

There total 11 articles about (S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (8S,10R,11R)-11-Benzyloxymethoxy-8-hydroxy-10-(4-methoxy-benzyloxy)-3,3-dimethyl-dodec-1-en-4-one

: 854931-17-2
(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

Guidance literature:: With camphor-10-sulfonic acid; In benzene; Heating;
DOI:10.1021/ol050511w

Reference yield:

: (2R,3R)-2-((benzyloxy)methoxy)hex-5-en-3-ol

: 854931-17-2
(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 9 steps

1: KH / tetrahydrofuran

2: O₃; NaHCO₃ / CH₂Cl₂; methanol / -78 °C

3: MgBr₂*Et₂O

4: 97 percent / imidazole / dimethylformamide

5: 92 percent / Rh(acac)2(CO)2; triarylphosphite-based ligand; H₂

6: 92 percent / indium / dimethylformamide

7: 94 percent / PCC; molecular sieves 4 Angstroem; NaOAc / CH₂Cl₂

8: 87 percent / pyridine*HF

9: 90 percent / camphorsulfonic acid / benzene / Heating

With 1H-imidazole; indium; Rh(acac)2(CO)2; 4 A molecular sieve; triarylphosphite-based ligand; camphor-10-sulfonic acid; hydrogen; sodium acetate; potassium hydride; sodium hydrogencarbonate; pyridine hydrogenfluoride; ozone; pyridinium chlorochromate; magnesium bromide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol050511w

Reference yield:

: 1-[(R)-1-((R)-1-Benzyloxymethoxy-ethyl)-but-3-enyloxymethyl]-4-methoxy-benzene

: 854931-17-2
(S)-2-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-6-(1,1-dimethyl-allyl)-3,4-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 8 steps

1: O₃; NaHCO₃ / CH₂Cl₂; methanol / -78 °C

2: MgBr₂*Et₂O

3: 97 percent / imidazole / dimethylformamide

4: 92 percent / Rh(acac)2(CO)2; triarylphosphite-based ligand; H₂

5: 92 percent / indium / dimethylformamide

6: 94 percent / PCC; molecular sieves 4 Angstroem; NaOAc / CH₂Cl₂

7: 87 percent / pyridine*HF

8: 90 percent / camphorsulfonic acid / benzene / Heating

With 1H-imidazole; indium; Rh(acac)2(CO)2; 4 A molecular sieve; triarylphosphite-based ligand; camphor-10-sulfonic acid; hydrogen; sodium acetate; sodium hydrogencarbonate; pyridine hydrogenfluoride; ozone; pyridinium chlorochromate; magnesium bromide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol050511w