N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline

Base Information

• Chemical Name: N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline
• CAS No.: 894810-83-4
• Molecular Formula: C₁₇H₁₈ClNO₃S
• Molecular Weight: 351.854
• Mol file: 894810-83-4.mol

Synonyms:N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline

Chemical Property of N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline

There total 4 articles about N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-allyl-N-p-toluenesulfonyl-3-chloroanthranilic acid methyl ester (894810-82-3) → N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline (894810-83-4)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3h;

DOI:10.1021/jo060308u

Reference yield:

methyl 3-chloroanthranilate (77820-58-7) → N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline (894810-83-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / pyridine / 3 h / Heating

2: 92 percent / K₂CO₃ / acetonitrile / 4 h / Heating

3: 100 percent / DIBAL / toluene / 3 h / -78 °C

With pyridine; diisobutylaluminium hydride; potassium carbonate; In toluene; acetonitrile;

DOI:10.1021/jo060308u

Reference yield:

2-amino-3-chlorobenzoic acid (6388-47-2) → N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline (894810-83-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / H₂SO₄ / 28 h / Heating

2: 40 percent / pyridine / 3 h / Heating

3: 92 percent / K₂CO₃ / acetonitrile / 4 h / Heating

4: 100 percent / DIBAL / toluene / 3 h / -78 °C

With pyridine; sulfuric acid; diisobutylaluminium hydride; potassium carbonate; In toluene; acetonitrile;

DOI:10.1021/jo060308u

upstream raw materials:

N-allyl-N-p-toluenesulfonyl-3-chloroanthranilic acid methyl ester

2-amino-3-chlorobenzoic acid

methyl 3-chloroanthranilate

N-p-toluenesulfonyl-3-chloroanthranilic acid methyl ester

Downstream raw materials:

7-chloro-N-p-tolylsulfonylindole

N-allyl-N-(2-chloro-6-vinyl-phenyl)-4-methyl-benzenesulfonamide

N-allyl-N-p-toluenesulfonyl-2-chloro-6-formylaniline