1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

Base Information

Chemical Name:1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid
CAS No.:1307810-20-3
Molecular Formula:C₂₆H₂₀F₃N₃O₅
Molecular Weight:511.457
Hs Code.:

Synonyms:1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

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Chemical Property of 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

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Technology Process of 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

There total 17 articles about 1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.5%

: 1307813-30-4
3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole-8-carbaldehyde

: 36476-78-5
3-azetidinecarboxylic acid

: 1307810-20-3
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

Guidance literature:: 3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-2,3-dihydrobenzo[b]oxepino-[4,5-d]isoxazole-8-carbaldehyde; 3-azetidinecarboxylic acid; With methanol; acetic acid; In 1,2-dichloro-ethane; at 67 ℃; for 2h;

With sodium cyanoborohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307810-20-3
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

4.2: 1 h / -78 °C

5.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

6.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.75 h / Reflux

7.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

8.1: triethylamine / dichloromethane / 0.53 h / 0 - 20 °C

8.2: 1 h / 80 °C

9.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

10.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

10.2: 4 h / 20 °C

11.1: methanol / acetic acid / 1,2-dichloro-ethane / 2 h / 67 °C

11.2: 20 °C

With 4-methyl-morpholine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N-chloro-succinimide; N-iodo-succinimide; osmium(VIII) oxide; lithium hydroxide monohydrate; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; lithium chloride; isobutyl chloroformate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 591-20-8
3-Bromophenol

: 1307810-20-3
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydrobenzo[6,7]oxepino[4,5-d]isoxazol-8-yl)methyl)-azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

2.1: lithium hydroxide / water; tetrahydrofuran / 3 h / 20 - 50 °C

3.1: diphenylphosphoranyl azide / 14 h / 20 - 100 °C / Cooling with ice

4.1: titanium tetrachloride / toluene / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0.53 h / 0 - 20 °C

5.2: 1 h / 80 °C

6.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

7.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

7.2: 4 h / 20 °C

8.1: methanol / acetic acid / 1,2-dichloro-ethane / 2 h / 67 °C

8.2: 20 °C

With methanol; osmium(VIII) oxide; diphenylphosphoranyl azide; titanium tetrachloride; caesium carbonate; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;