2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione

Base Information

• Chemical Name: 2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione
• CAS No.: 321918-24-5
• Molecular Formula: C₁₅H₁₆N₂O₄
• Molecular Weight: 288.303

Synonyms:2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione

Chemical Property of 2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione

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Technology Process of 2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione

There total 2 articles about 2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2',3',4',5',6',7'-hexahydro-6'-imino-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]-diazepine)-3',7'-dione (321918-08-5) → 2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione (321918-24-5)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1021/ol0068187

Reference yield:

9-chloro-4-(4-methoxy-benzyl)-4,7-diaza-spiro[2.6]nonane-5,8-dione → 2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione (321918-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / sodium azide / dimethylsulfoxide / 5 h / 80 - 90 °C

2: 67 percent / HCl / methanol / 2 h / 0 - 20 °C

With hydrogenchloride; sodium azide; In methanol; dimethyl sulfoxide;

DOI:10.1021/ol0068187

Reference yield: 91.0%

2',3',4',5',6',7'-hexahydro-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]diazepine)-3',6',7'-trione (321918-24-5) → 2,3,4,5,7,8-hexahydro-1-(4-methoxybenzyl)furo[1H][3,2-e][1,4]diazepine-2,5-dione (321918-26-7)

Guidance literature:

at 200 ℃; for 0.5h; under 3.75038E-05 Torr;

DOI:10.1021/ol0068187

upstream raw materials:

2',3',4',5',6',7'-hexahydro-6'-imino-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]-diazepine)-3',7'-dione

Downstream raw materials:

2,3,4,5,7,8-hexahydro-1-(4-methoxybenzyl)furo[1H][3,2-e][1,4]diazepine-2,5-dione

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