4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:942189-35-7
Molecular Formula:C₁₉H₂₄N₄O₂
Molecular Weight:340.425
Hs Code.:
Mol file:942189-35-7.mol

Synonyms:4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(4-(pyrimidin-2-yl)phenyl)piperazine-1-carboxylate 97%
1g
$ 474.00

Total 2 raw suppliers

Chemical Property of 4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Boiling Point:438.4±45.0 °C(Predicted)
PKA:2.48±0.13(Predicted)
Density:1.167±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(4-(pyrimidin-2-yl)phenyl)piperazine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 457613-78-4
4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid

: 942189-35-7
4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield:

: 1-(4-Bromophenyl)Piperazine Monohydrochloride

: 942189-35-7
4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 18.17 h / 20 °C

3.1: ammonium chloride / tetrahydrofuran; hexanes; water / 0.08 h

3.2: 1 h

4.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 8 h / 80 °C

With n-butyllithium; potassium carbonate; ammonium chloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexanes; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 942189-35-7
4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 18.17 h / 20 °C

3.1: ammonium chloride / tetrahydrofuran; hexanes; water / 0.08 h

3.2: 1 h

4.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 8 h / 80 °C

With n-butyllithium; potassium carbonate; ammonium chloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexanes; dichloromethane; water; N,N-dimethyl-formamide;