ethyl 3-amino-3-phenyl-2-thioformylacrylate

Base Information

• Chemical Name: ethyl 3-amino-3-phenyl-2-thioformylacrylate
• CAS No.: 124413-13-4
• Molecular Formula: C₁₂H₁₃NO₂S
• Molecular Weight: 235.307
• Mol file: 124413-13-4.mol

Synonyms:ethyl 3-amino-3-phenyl-2-thioformylacrylate

Chemical Property of ethyl 3-amino-3-phenyl-2-thioformylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-amino-3-phenyl-2-thioformylacrylate

There total 2 articles about ethyl 3-amino-3-phenyl-2-thioformylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((E)-3-Amino-2-ethoxycarbonyl-3-phenyl-allylidene)-dimethyl-ammonium; GENERIC INORGANIC ANION → ethyl 3-amino-3-phenyl-2-thioformylacrylate (124413-13-4)

Guidance literature:

With sodium hydrogensulfide; In dichloromethane; Yield given;

DOI:10.1039/P19890001241

Reference yield:

ethyl 3-amino-3-phenyl-2-propenoate (124413-63-4) → ethyl 3-amino-3-phenyl-2-thioformylacrylate (124413-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / tetrahydrofuran / 1) 1 h, 0 deg C, 2) 3 h, 30 deg C

2: 2M aq. NaHS / CH₂Cl₂

With sodium hydrogensulfide; trichlorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1039/P19890001241

Reference yield: 97.0%

ethyl 3-amino-3-phenyl-2-thioformylacrylate (124413-13-4) → ethyl 3-phenyl-1,2-thiazole-4-carboxylate (67049-00-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In ethanol; at 75 ℃; for 3h;

DOI:10.1039/P19890001241

upstream raw materials:

ethyl 3-amino-3-phenyl-2-propenoate

Downstream raw materials:

ethyl 3-phenyl-1,2-thiazole-4-carboxylate