(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide
• CAS No.: 1616100-76-5
• Molecular Formula: C₂₃H₂₈F₂N₄O₃S
• Molecular Weight: 478.563
• Mol file: 1616100-76-5.mol

Synonyms:(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

There total 11 articles about (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide (1616100-75-4) → (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide (1616100-76-5)

Guidance literature:

With lithium tri-t-butoxyaluminum hydride; In diethyl ether; at -78 - -25 ℃; for 0.916667h;

Reference yield:

2,4-dimethyl-5-acetyloxazole (23012-25-1) → (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide (1616100-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 2 h / -78 °C

2.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 0.92 h / -78 - -25 °C

With potassium hexamethylsilazane; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; diethyl ether;

Reference yield:

2,4-difluoro-5-(pyrimidin-5-yl)benzaldehyde (1415208-99-9) → (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide (1616100-76-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diethyl ether / 15 h / 20 - 75 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

3.1: tetrahydrofuran / 20 h / 65 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

4.2: 2 h / -78 °C

5.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 0.92 h / -78 - -25 °C

With oxalyl dichloride; potassium hexamethylsilazane; dimethyl sulfoxide; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; diethyl ether; dichloromethane;

upstream raw materials:

2,4-difluoro-5-(pyrimidin-5-yl)benzaldehyde

2,4-dimethyloxazole-5-carbaldehyde

2,4-dimethyl-5-acetyloxazole

(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(1R,3S)-3-amino-3-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-1-(2,4-dimethyloxazol-5-yl)butan-1-ol

N-(((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,4-dimethyloxazol-5-yl)-4-hydroxybutan-2-yl)carbamothioyl)benzamide

(4S,6S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,4-dimethylisoxazol-5-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine