(1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

• Chemical Name: (1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
• CAS No.: 1257646-79-9
• Molecular Formula: C₃₉H₃₆N₂O₉
• Molecular Weight: 676.723
• Mol file: 1257646-79-9.mol

Synonyms:(1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Chemical Property of (1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

There total 1 articles about (1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,3R,4R,7S)-1-benzoyloxymethyl-7-hydroxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (1257646-78-8) + 4,4'-dimethoxytrityl chloride (40615-36-9) → (1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (1257646-79-9)

Guidance literature:

With 2,6-dimethylpyridine; silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1039/c0ob00346h

Reference yield: 91.0%

(1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (1257646-79-9) → (1S,3R,4R,7S)-7-(4,4'-dimethoxytrityloxy)-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:

With water; potassium carbonate; In methanol; dichloromethane; at 20 ℃; for 40h;

DOI:10.1039/c0ob00346h

Reference yield:

1,2,4-Triazole (288-88-0) + (1R,3R,4R,7S)-1-benzoyloxymethyl-7-(4,4'-dimethoxytrityloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (1257646-79-9) → C41H37N5O8

Guidance literature:

With triethylamine; trichlorophosphate; In acetonitrile; at 0 - 20 ℃;

DOI:10.1039/c0ob00346h

upstream raw materials:

(1R,3R,4R,7S)-1-benzoyloxymethyl-7-hydroxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

4,4'-dimethoxytrityl chloride