(2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid

Base Information

• Chemical Name: (2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid
• CAS No.: 1224724-29-1
• Molecular Formula: C₂₀H₁₆ClN₂O₃PS
• Molecular Weight: 430.851
• Mol file: 1224724-29-1.mol

Synonyms:(2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid

Chemical Property of (2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid

There total 1 articles about (2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid (1224724-29-1)

Guidance literature:

Reference yield:

(2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid (1224724-29-1) + 3-fluoro-4-methoxybenzyl alcohol (96047-32-4) → (5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanylmethyl)phosphonic acid mono-(3-fluoro-4-methoxybenzyl) ester (1224724-31-5)

Guidance literature:

(2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid; With thionyl chloride; for 0.25h; Reflux;

3-fluoro-4-methoxybenzyl alcohol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

(2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid (1224724-29-1) + (S)-(-)-1-(3-Chlorophenyl)-1,3-propanediol (625095-57-0) → 5-biphenyl-4-yl-6-chloro-2-(4-(3-chlorophenyl)-2-oxo-2λ5-[1,3,2]-dioxaphosphinan-2-ylmethylsulfanyl)-1H-benzoimidazole (1224724-30-4)

Guidance literature:

(2-(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanyl)methyl)phosphonic acid; With thionyl chloride; for 0.75h; Reflux;

(S)-(-)-1-(3-Chlorophenyl)-1,3-propanediol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;

With water; ammonium chloride; In dichloromethane;

Downstream raw materials:

(5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanylmethyl)phosphonic acid mono-(3-fluoro-4-methoxybenzyl) ester

5-biphenyl-4-yl-6-chloro-2-(4-(3-chlorophenyl)-2-oxo-2λ5-[1,3,2]-dioxaphosphinan-2-ylmethylsulfanyl)-1H-benzoimidazole

thiopropionic acid S-(2-((5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanylmethyl)-hydroxyphosphinoyloxy)ethyl) ester

thiopropionic acid S-(2-((5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanylmethyl)-(2-propionylsulfanylethoxy)phosphinoyloxy)ethyl) ester