(S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate

Base Information

• Chemical Name: (S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate
• CAS No.: 1207188-14-4
• Molecular Formula: C₃₅H₃₃N₃O₅S
• Molecular Weight: 607.73

Synonyms:(S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate

Chemical Property of (S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate

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Technology Process of (S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate

There total 1 articles about (S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(S)-methyl 3-(2-(benzylsulfanyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate (1207188-10-0) → (S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate (1207188-14-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2009.11.077

Reference yield: 63.0%

morpholine (110-91-8,99108-56-2) + (S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate (1207188-14-4) → (S)-methyl 3-(6-methyl-2-morpholinopyrimidin-4-yloxy)-2-(tritylamino)propanoate (1207188-17-7)

Guidance literature:

In 1,4-dioxane; at 60 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.11.077

Reference yield: 40.0%

(S)-methyl 3-(2-(benzylsulfonyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate (1207188-14-4) + (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) → (S)-methyl 3-(2-(4-(2-(S)-tert-butoxycarbonylamino-2-methoxycarbonylethyl)phenoxy)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate (1207188-79-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.11.077

upstream raw materials:

(S)-methyl 3-(2-(benzylsulfanyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate

Downstream raw materials:

(S)-methyl 3-(6-methyl-2-morpholinopyrimidin-4-yloxy)-2-(tritylamino)propanoate

(S)-methyl 3-(2-(4-(2-(S)-tert-butoxycarbonylamino-2-methoxycarbonylethyl)phenoxy)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate

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