9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

Base Information

Chemical Name:9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine
CAS No.:131372-52-6
Molecular Formula:C₃₇H₄₂F₃N₅O₇SSi
Molecular Weight:785.916
Hs Code.:

Synonyms:9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

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Chemical Property of 9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

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Technology Process of 9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

There total 6 articles about 9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 83373-09-5
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>adenine

: 131372-52-6
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

Guidance literature:: With dmap; triethylamine; In dichloromethane; 1)-40 to -20 deg C, 1 h, 2) rt, 2 h;
DOI:10.1055/s-1990-27048

Reference yield:

: 69504-04-7
5'-O-(monomethoxytrityl)-2'-O-<(tert-butyl)dimethylsilyl>adenosine

: 131372-52-6
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / DMAP, Et₃N / CH₂Cl₂ / 1) -40 to -20 deg C, 1 h, 2) rt, 2 h

2: 72 percent / HMPT (hexamethylphosphoric triamide) / 14 h / Ambient temperature

3: 86 percent / Me₂NH / methanol / 1) 0 deg C, 12 - 14 h, 2) rt, 2 h

4: 86 percent / DMAP, Et₃N / CH₂Cl₂ / 1)-40 to -20 deg C, 1 h, 2) rt, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; dimethyl amine; triethylamine; In methanol; dichloromethane;
DOI:10.1055/s-1990-27048

Reference yield:

: 131372-49-1
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

: 131372-52-6
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-trifluoromethanesulfonyl-β-D-xylofuranosyl>adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Me₂NH / methanol / 1) 0 deg C, 12 - 14 h, 2) rt, 2 h

2: 86 percent / DMAP, Et₃N / CH₂Cl₂ / 1)-40 to -20 deg C, 1 h, 2) rt, 2 h

With dmap; dimethyl amine; triethylamine; In methanol; dichloromethane;
DOI:10.1055/s-1990-27048