C₂₅H₃₄BFN₄O₆

Base Information

• Chemical Name: C₂₅H₃₄BFN₄O₆
• CAS No.: 1612854-11-1
• Molecular Formula: C₂₅H₃₄BFN₄O₆
• Molecular Weight: 516.378
• Mol file: 1612854-11-1.mol

Synonyms:C₂₅H₃₄BFN₄O₆

Chemical Property of C₂₅H₃₄BFN₄O₆

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₂₅H₃₄BFN₄O₆

There total 1 articles about C₂₅H₃₄BFN₄O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate (203866-16-4) → C25H34BFN4O6 (1612854-11-1)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium hydroxide; water / tetrahydrofuran / 2 h / 0 - 20 °C

2: hydrogenchloride / ethyl acetate / 8 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

5: lithium hydroxide; water / dichloromethane / 5 h / 0 - 20 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield: 45.0%

C35H40F4N4O6S (1612854-07-5) + C25H34BFN4O6 (1612854-11-1) → C53H62F2N8O7 (1612854-12-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 3h; Inert atmosphere;

upstream raw materials:

1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate

Downstream raw materials:

C₅₃H₆₂F₂N₈O₇