3-methylene-1-tosylazetidine

Base Information

Chemical Name:3-methylene-1-tosylazetidine
CAS No.:1349199-59-2
Molecular Formula:C₁₁H₁₃NO₂S
Molecular Weight:223.296
Hs Code.:

Synonyms:3-methylene-1-tosylazetidine

Suppliers and Price of 3-methylene-1-tosylazetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of 3-methylene-1-tosylazetidine

Chemical Property:

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 3-methylene-1-tosylazetidine

There total 3 articles about 3-methylene-1-tosylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2065-66-9
methyl-triphenylphosphonium iodide

: 76543-27-6
1-(p-toluenesulfonyl) azetidin-3-one

: 1349199-59-2
3-methylene-1-tosylazetidine

Guidance literature:: methyl-triphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

1-(p-toluenesulfonyl) azetidin-3-one; In tetrahydrofuran; diethyl ether; at 0 ℃;
DOI:10.1002/anie.202103278

Reference yield: 53.0%

: 1349199-52-5
(3-(bromomethyl)-1-tosylazetidin-3-yl)(furan-2-yl)methanol

: 1349199-59-2
3-methylene-1-tosylazetidine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1021/ol2028459

Reference yield:

: 1233143-50-4
3-(bromomethyl)-1-tosylazetidine-3-carbaldehyde

: 1349199-59-2
3-methylene-1-tosylazetidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1.05 h / -78 - -60 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexanes;
DOI:10.1021/ol2028459