benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

Base Information

Chemical Name:benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate
CAS No.:1644598-80-0
Molecular Formula:C₁₇H₁₅FN₂O₃
Molecular Weight:314.316
Hs Code.:

Synonyms:benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

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Chemical Property of benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

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Technology Process of benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

There total 6 articles about benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1644598-79-7
benzyl 5-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

: 1644598-80-0
benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

Guidance literature:: With ammonium chloride; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 19h;
DOI:10.1002/anie.201402750

Reference yield:

: 345-16-4
5-fluoro-2-hydroxybenzoic acid

: 1644598-80-0
benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 2 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Microwave irradiation; Sealed tube

2.2: 49 h / 20 - 110 °C

3.1: trifluoroacetic acid / toluene / 23 h / 20 °C

4.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

5.1: caesium carbonate / 13 h / 85 °C

6.1: zinc; ammonium chloride / N,N-dimethyl-formamide / 19 h / 20 °C

With sulfuric acid; nitric acid; potassium carbonate; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201402750

Reference yield:

: 130046-91-2
5-fluoro-2-hydroxy-3-nitrobenzoic acid

: 1644598-80-0
benzyl (3R)-7-fluoro-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Microwave irradiation; Sealed tube

1.2: 49 h / 20 - 110 °C

2.1: trifluoroacetic acid / toluene / 23 h / 20 °C

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

4.1: caesium carbonate / 13 h / 85 °C

5.1: zinc; ammonium chloride / N,N-dimethyl-formamide / 19 h / 20 °C

With potassium carbonate; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201402750