(1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane

Base Information

• Chemical Name: (1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane
• CAS No.: 1631748-49-6
• Molecular Formula: C₂₁H₂₄O₂
• Molecular Weight: 308.42
• Mol file: 1631748-49-6.mol

Synonyms:(1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane

Chemical Property of (1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

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Technology Process of (1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane

There total 1 articles about (1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(1R,2R,4R,5R)-exo,exo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane-endo,endo-2,5-diol (1631748-50-9) → (1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane (1631748-49-6)

Guidance literature:

With perchloric acid; palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃; for 24h; under 1520.1 Torr; Autoclave;

DOI:10.1002/cjoc.201400162

Reference yield: 95.0%

(1R,2R,4R,5R)-endo,endo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane (1631748-49-6) → (1R,2R,4R,5R)-endo,endo-2,5-di(2-hydroxy)phenylbicyclo[2, 2, 1]heptane (1631748-51-0)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 ℃; for 24.5h; Inert atmosphere;

DOI:10.1002/cjoc.201400162

upstream raw materials:

(1R,2R,4R,5R)-exo,exo-2,5-di(2-methoxy)phenylbicyclo[2,2,1]heptane-endo,endo-2,5-diol

Downstream raw materials:

(1R,2R,4R,5R)-endo,endo-2,5-di(2-hydroxy)phenylbicyclo[2, 2, 1]heptane