N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

Base Information

Chemical Name:N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide
CAS No.:1373939-41-3
Molecular Formula:C₂₃H₂₀F₂N₄O₃
Molecular Weight:438.434
Hs Code.:

Synonyms:N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

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Chemical Property of N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

Chemical Property:

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Technology Process of N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

There total 8 articles about N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373938-01-2
N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2,6-difluorobenzamide

: 1373939-41-3
N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; for 0.166667h;

Reference yield:

: 7697-26-9
3-bromo-4-methylbenzoic acid

: 1373939-41-3
N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3 h / 20 °C

2.1: tetrahydrofuran / -20 - 20 °C

2.2: 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

4.1: hydroxylamine hydrochloride; pyridine / methanol / 12 h / Reflux

5.1: chromium(VI) oxide; sulfuric acid / water; acetic acid / 0.5 h / 100 °C

6.1: potassium acetate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 100 °C / Inert atmosphere

7.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

8.1: sodium tetrahydroborate; methanol / 0.17 h / 20 °C

With pyridine; chromium(VI) oxide; methanol; sodium tetrahydroborate; sulfuric acid; hydroxylamine hydrochloride; potassium acetate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;

Reference yield:

: 1373939-84-4
1-(3-bromo-4-methylphenyl)-3-methylbut-2-en-1-one

: 1373939-41-3
N-(5-(5-(5,5-dimethyl-4-hydroxy-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

2: hydroxylamine hydrochloride; pyridine / methanol / 12 h / Reflux

3: chromium(VI) oxide; sulfuric acid / water; acetic acid / 0.5 h / 100 °C

4: potassium acetate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 100 °C / Inert atmosphere

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

6: sodium tetrahydroborate; methanol / 0.17 h / 20 °C

With pyridine; chromium(VI) oxide; methanol; sodium tetrahydroborate; sulfuric acid; hydroxylamine hydrochloride; potassium acetate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid;