2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Base Information

Chemical Name:2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine
CAS No.:1416366-91-0
Molecular Formula:C₂₂H₂₇BrFN₃O₂
Molecular Weight:464.378
Hs Code.:

Synonyms:2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

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Chemical Property of 2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

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Technology Process of 2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

There total 6 articles about 2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1416366-90-9
((1R,2R)-2-(1-(5-(methoxymethyl)pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)methanol

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1416366-91-0
2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: ((1R,2R)-2-(1-(5-(methoxymethyl)pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)methanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

4-bromo-2-fluorobenzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: ((1R,2R)-2-(piperidin-4-yl)cyclopropyl)methanol hydrochloride

: 1416366-91-0
2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

1.2: 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C

2.2: 0 - 20 °C

With sodium hydride; caesium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.5b00207

Reference yield:

: 1416366-00-1
tert-butyl 4-[(1S,2R)-2-(hydroxymethyl)cyclopropyl]piperidine-1-carboxylate

: 1416366-91-0
2-(4-((1R,2R)-2-(((4-bromo-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C

3.2: 0 - 20 °C

With hydrogenchloride; sodium hydride; caesium carbonate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.5b00207