Technology Process of ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate
There total 7 articles about ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
for 0.5h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3: triethylamine / tetrahydrofuran / 1 h / Cooling with ice
4: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 0.5 h / Cooling with ice
With
pyridine; trifluoromethylsulfonic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; water / methanol / 1 h / 60 °C
1.2: pH 4 / Cooling with ice
2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice
5.1: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 0.5 h / Cooling with ice
With
pyridine; trifluoromethylsulfonic anhydride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;