ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

Base Information

Chemical Name:ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate
CAS No.:1310809-56-3
Molecular Formula:C₂₄H₂₄N₆O₆
Molecular Weight:492.491
Hs Code.:

Synonyms:ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

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Chemical Property of ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

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Technology Process of ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

There total 7 articles about ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310807-59-0
ethyl {2-[(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)carbonyl]hydrazino}(oxo)acetate

: 1310809-56-3
ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

Guidance literature:: With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; for 0.5h; Cooling with ice;

Reference yield:

: 1310807-57-8
5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridine-2-carboxylic acid

: 1310809-56-3
ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

4: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 0.5 h / Cooling with ice

With pyridine; trifluoromethylsulfonic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₂₂H₂₄N₄O₅

: 1310809-56-3
ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / methanol / 1 h / 60 °C

1.2: pH 4 / Cooling with ice

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

5.1: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 0.5 h / Cooling with ice

With pyridine; trifluoromethylsulfonic anhydride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;