2-chloro-3-methyl-1H-indole

Base Information

• Chemical Name: 2-chloro-3-methyl-1H-indole
• CAS No.: 51206-73-6
• Molecular Formula: C₉H₈ClN
• Molecular Weight: 165.622
• Mol file: 51206-73-6.mol

Synonyms:2-chloro-3-methyl-1H-indole

Chemical Property of 2-chloro-3-methyl-1H-indole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-3-methyl-1H-Indole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-3-methyl-1H-indole

There total 2 articles about 2-chloro-3-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-Methylindole (83-34-1) → 2-chloro-3-methyl-1H-indole (51206-73-6)

Guidance literature:

With copper dichloride; In acetonitrile; for 8h; Ambient temperature;

Reference yield: 1.0%

3-methylindolin-2-one (1504-06-9) + 4,6-dimethoxy-2,3-diphenyl-1H-indole (91107-10-7) → 2-chloro-3-methyl-1H-indole (51206-73-6) + 4,6-dimethoxy-7-(3'-methylindol-2'-yl)-2,3-diphenylindole

Guidance literature:

With trichlorophosphate; In chloroform;

DOI:10.1016/0040-4020(96)00305-5

Reference yield: 90.0%

2-chloro-3-methyl-1H-indole (51206-73-6) → 3-Methylindole (83-34-1)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol;

DOI:10.1055/s-1980-29020

upstream raw materials:

3-Methylindole

3-methylindolin-2-one

4,6-dimethoxy-2,3-diphenyl-1H-indole

Downstream raw materials:

3-Methylindole

Refernces

• 1、 Tang, Shi,Li, Jin-Heng,Xie, Ye-Xiang,Wang, Nai-Xing. "Halogenation of indoles with copper(II) halides: Selective synthesis of 2-halo-, 3-halo-, and 2,3-dibromoindoles". . p. 1535 - 1541. Retrieved 2008/02/08.
• 2、 Balogh-Hergovich, Eva,Speier, Gabor. "The chlorination of indoles by copper(II) chloride". . p. 2305 - 2309. Retrieved 2007/10/02.