methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

Base Information

• Chemical Name: methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide
• CAS No.: 1426397-02-5
• Molecular Formula: C₁₈H₁₄N₄O₆S
• Molecular Weight: 414.398
• Mol file: 1426397-02-5.mol

Synonyms:methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

Chemical Property of methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

There total 1 articles about methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C12H11NO6S + 4-nitrophenylhydrazine hydrochloride (636-99-7) → methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide (1426397-02-5)

Guidance literature:

In methanol; for 6h; Reflux;

DOI:10.1021/jm301643a

Reference yield: 98.0%

methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide (1426397-02-5) → 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylic acid 5,5-dioxide (1426397-08-1)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Reflux;

DOI:10.1021/jm301643a

Reference yield:

methyl 4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide (1426397-02-5) → C24H20N6O7S2 (1426397-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 1 h / Reflux

2: thionyl chloride / 1 h / Reflux

3: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm301643a

upstream raw materials:

4-nitrophenylhydrazine hydrochloride

Downstream raw materials:

4-methyl-1-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylic acid 5,5-dioxide

C₂₄H₂₀N₆O₇S₂

C₂₄H₂₂N₆O₅S₂