N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

Base Information

Chemical Name:N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2
CAS No.:945867-07-2
Molecular Formula:C₃₆H₄₉NO₂Si₂
Molecular Weight:583.962
Hs Code.:

Synonyms:N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

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Technology Process of N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

There total 5 articles about N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 945867-06-1
N-{3-bromo-5-[2-(triisopropylsilyl)ethynyl]benzyl}coumarin 2

: 1066-54-2
trimethylsilylacetylene

: 945867-07-2
N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; at 80 ℃; for 18h;
DOI:10.1002/ejoc.200700118

Reference yield:

: 945867-05-0
N-(3,5-dibromobenzyl)coumarin 2

: 945867-07-2
N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / Pd(PPh₃)4 / triethylamine / 48 h / 80 °C

2: 85 percent / CuI / Pd(PPh₃)4 / triethylamine / 18 h / 80 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; 1: Sonogashira coupling reaction / 2: Sonogashira coupling reaction;
DOI:10.1002/ejoc.200700118

Reference yield:

: 56908-88-4
3,5-dibromobenzyl bromide

: 945867-07-2
N-{3-[2-(triisopropylsilyl)ethynyl]-5-[2-(trimethylsilyl)ethynyl]benzyl}coumarin 2

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / K₂CO₃ / acetonitrile / 120 h / Heating

2: 56 percent / Pd(PPh₃)4 / triethylamine / 48 h / 80 °C

3: 85 percent / CuI / Pd(PPh₃)4 / triethylamine / 18 h / 80 °C

With copper(l) iodide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; acetonitrile; 2: Sonogashira coupling reaction / 3: Sonogashira coupling reaction;
DOI:10.1002/ejoc.200700118