2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

Base Information

Chemical Name:2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide
CAS No.:1428443-69-9
Molecular Formula:C₂₂H₂₂N₆O₂
Molecular Weight:402.456
Hs Code.:

Synonyms:2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

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Chemical Property of 2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

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Technology Process of 2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

There total 4 articles about 2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1428443-61-1
2-azido-1-(2-phenyl-1H-indol-3-yl)-ethanone

: 1428443-68-8
2-(methylamino)-N-(prop-2-yn-1-yl)acetamide hydrochloride

: 1428443-69-9
2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; for 52h; Sonication;
DOI:10.1039/c2ra21902f

Reference yield:

: 948-65-2
2-phenyl-indole

: 1428443-69-9
2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / toluene / 60 °C / Inert atmosphere

2: sodium azide / dimethyl sulfoxide / 2.25 h / Inert atmosphere

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 52 h / Sonication

With pyridine; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; dimethyl sulfoxide; toluene; tert-butyl alcohol; 3: |Huisgen Cycloaddition;
DOI:10.1039/c2ra21902f

Reference yield:

: 59050-37-2
2,2,2-trifluoro-1-(2-phenyl-1H-indol-3-yl)ethan-1-one

: 1428443-69-9
2-(methylamino)-N-((1-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water / 65 - 80 °C

2: pyridine / toluene / 60 °C / Inert atmosphere

3: sodium azide / dimethyl sulfoxide / 2.25 h / Inert atmosphere

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 52 h / Sonication

With pyridine; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; sodium hydroxide; In water; dimethyl sulfoxide; toluene; tert-butyl alcohol; 4: |Huisgen Cycloaddition;
DOI:10.1039/c2ra21902f