Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI)

Base Information

Chemical Name:Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI)
CAS No.:73565-76-1
Molecular Formula:C₁₀H₁₂O
Molecular Weight:148.205
Hs Code.:
Mol file:73565-76-1.mol

Synonyms:Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI)

Suppliers and Price of Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI)

Chemical Property:

PSA：17.07000
LogP:1.95370

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI)

There total 2 articles about Bicyclo[2.2.1]hept-5-ene-2-carboxaldehyde, 2-methyl-3-methylene-, endo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30453-39-5
2-methyl-buta-2,3-dienal

: 542-92-7,25568-84-7,7313-32-8
cyclopenta-1,3-diene

: (1RS,2RS,4SR)-2-methyl-3-methylidenebicyclo[2.2.1]hept-5-ene-2-carbaldehyde

: 73565-76-1
(1R,2S,4S)-2-Methyl-3-methylene-bicyclo[2.2.1]hept-5-ene-2-carbaldehyde

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -20 ℃; for 1h; Overall yield = 10 %; Inert atmosphere;
DOI:10.1002/cbdv.201400060

Reference yield:

: 73565-76-1
2-Methyl-3-methylene-bicyclo[2.2.1]hept-5-ene-2-carbaldehyde

Guidance literature:: entspr. Alkohol 4;
DOI:10.1016/S0040-4039(01)86475-3

Reference yield:

: 73565-76-1
(1R,2S,4S)-2-Methyl-3-methylene-bicyclo[2.2.1]hept-5-ene-2-carbaldehyde

: 77228-94-5,77286-00-1
C₁₉H₂₁NS

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylsulfoxide / Ambient temperature

2: acidic silica gel / CH₂Cl₂ / 48 h

3: 92 percent / CH₃S(O)CH₂Na / dimethylsulfoxide / Horner-Emmons reaction

4: 96 percent / Mg / methanol

5: 100 percent / CH₂Cl₂ / 0 °C

6: 81 percent / LiN(C₂H₅)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With lithium diethylamide; silica gel; sodium methylsulfinylmethanide; magnesium; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/0040-4039(80)88100-7