2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide

Base Information

• Chemical Name: 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide
• CAS No.: 696601-64-6
• Molecular Formula: C₂₂H₂₁BrClN₃O
• Molecular Weight: 458.785

Synonyms:2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide

Chemical Property of 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide

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Technology Process of 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide

There total 3 articles about 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-Aminoethyl)pyridine (13258-63-4) + (2-bromo-phenyl)-(2-chloro-4-methyl-phenylamino)-acetic acid → 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide (696601-64-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1021/jm049974i

Reference yield:

2-chloro-4-methyl-benzenamine (615-65-6) → 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide (696601-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 70 °C

2: HATU; diisopropylethylamine / dimethylsulfoxide / 12 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; toluene;

DOI:10.1021/jm049974i

Reference yield:

(2-bromophenyl)boronic acid (244205-40-1) → 2-(2-bromo-phenyl)-2-(2-chloro-4-methyl-phenylamino)-N-(2-pyridin-4-yl-ethyl)-acetamide (696601-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 70 °C

2: HATU; diisopropylethylamine / dimethylsulfoxide / 12 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; toluene;

DOI:10.1021/jm049974i

upstream raw materials:

4-(2-Aminoethyl)pyridine

2-chloro-4-methyl-benzenamine

(2-bromophenyl)boronic acid

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