tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate
CAS No.:937183-75-0
Molecular Formula:C₂₅H₃₂FIN₂O₅
Molecular Weight:586.442
Hs Code.:

Synonyms:tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

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Chemical Property of tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

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Technology Process of tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

There total 12 articles about tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 937183-75-0
tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

Guidance literature:

Reference yield:

: 937183-68-1
tert-butyl (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

: 937183-75-0
tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

Guidance literature:: tert-butyl (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate; With bis(tri-n-butyltin); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 18h;

With iodine; In tetrahydrofuran; at 0 ℃; for 1h; Further stages.;
DOI:10.1021/jm070025+

Reference yield:

: 13466-43-8
3-bromo-pyridin-2-ol

: 937183-75-0
tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / N-iodosuccinimide / acetonitrile / 1 h / Heating

2.1: 75 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3.1: 94 percent / K₂CO₃; tetrabutylammonium bromide / Pd(OAc)2 / dimethylformamide / 2 h / 65 °C

4.1: bis(tributyltin) / Pd(PPh₃)4 / toluene / 18 h / 110 °C

4.2: 0.018 g / I₂ / tetrahydrofuran / 1 h / 0 °C

With N-iodo-succinimide; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; bis(tri-n-butyltin); potassium carbonate; triphenylphosphine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Mitsunobu reaction / 3.1: Heck reaction / 4.1: Stille coupling;
DOI:10.1021/jm070025+