3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide

Base Information

• Chemical Name: 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide
• CAS No.: 884328-44-3
• Molecular Formula: C₂₄H₂₇ClN₄OS
• Molecular Weight: 455.024

Synonyms:3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide

Chemical Property of 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide

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Technology Process of 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide

There total 6 articles about 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenylamine (865787-16-2) + 3,3-Dimethylacryloyl chloride (3350-78-5) → 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide (884328-44-3)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

3-{4-[2-(5-chloro-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole (865787-10-6) → 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide (884328-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / H₂; Et₃N / Raney Ni

2: 97 percent / Et₃N / tetrahydrofuran

With hydrogen; triethylamine; nickel; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

1-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-2-(5-chloro-2-nitro-phenyl)-ethanone (865787-04-8) → 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenyl}-amide (884328-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / BH₃*SMe₂ / toluene / Heating

2: 66 percent / H₂; Et₃N / Raney Ni

3: 97 percent / Et₃N / tetrahydrofuran

With dimethylsulfide borane complex; hydrogen; triethylamine; nickel; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2005.06.097

upstream raw materials:

2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-chloro-phenylamine

3,3-Dimethylacryloyl chloride

3-{4-[2-(5-chloro-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

1-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-2-(5-chloro-2-nitro-phenyl)-ethanone

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