(((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

Base Information

Chemical Name:(((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane
CAS No.:1431302-69-0
Molecular Formula:C₁₅H₂₈BrClOSi
Molecular Weight:367.829
Hs Code.:

Synonyms:(((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

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Chemical Property of (((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

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Technology Process of (((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

There total 7 articles about (((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1431302-68-9
(((1R,2S,4S)-2-bromo-1-methyl-4-(prop-1-en-2-yl)cyclohexyl)oxy)(isopropyl)dimethylsilane

: 1431302-69-0
(((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

Guidance literature:: With sodium hypochlorite; cerium(III) chloride heptahydrate; In dichloromethane; water; at 0 - 20 ℃; for 2h;
DOI:10.1021/ol400754e

Reference yield:

: 288264-99-3,7086-80-8
(2R,5S)-2-hydroxy-2-methyl-5-(prop-1-en-2-yl)cyclohexanone

: 1431302-69-0
(((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-dimethylpyridine / dichloromethane / -78 - 20 °C / Inert atmosphere

2: methanol / 5 h / 20 °C

3: n-butyllithium; copper(ll) bromide / tetrahydrofuran; hexane; tert-butyl alcohol / 0 - 20 °C / Inert atmosphere

4: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / benzene / 1 h / Reflux

5: cerium(III) chloride heptahydrate; sodium hypochlorite / dichloromethane; water / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; sodium hypochlorite; n-butyllithium; 2,2'-azobis(isobutyronitrile); cerium(III) chloride heptahydrate; tris-(trimethylsilyl)silane; copper(ll) bromide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1021/ol400754e

Reference yield:

: 59121-82-3
(1R,2R,4S)-1-methyl-4-(prop-1-en-2-yl)cyclohexane-1,2-diol

: 1431302-69-0
(((1R,2S,4S)-2-bromo-4-(3-chloroprop-1-en-2-yl)-1-methylcyclohexyl)oxy)(isopropyl)dimethylsilane

Guidance literature:: Multi-step reaction with 6 steps

1: 2-iodoxybenzoic acid / ethyl acetate / 16 h / Reflux

2: 2,6-dimethylpyridine / dichloromethane / -78 - 20 °C / Inert atmosphere

3: methanol / 5 h / 20 °C

4: n-butyllithium; copper(ll) bromide / tetrahydrofuran; hexane; tert-butyl alcohol / 0 - 20 °C / Inert atmosphere

5: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / benzene / 1 h / Reflux

6: cerium(III) chloride heptahydrate; sodium hypochlorite / dichloromethane; water / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; sodium hypochlorite; n-butyllithium; 2-iodoxybenzoic acid; 2,2'-azobis(isobutyronitrile); cerium(III) chloride heptahydrate; tris-(trimethylsilyl)silane; copper(ll) bromide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; tert-butyl alcohol; benzene;
DOI:10.1021/ol400754e