8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

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Chemical Name:8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one
CAS No.:286372-29-0
Molecular Formula:C₄₆H₇₈N₂O₇S₂Si₃
Molecular Weight:919.523
Hs Code.:

8-(1-benzenesulfonyl-4-{6-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(<i>tert</i>-butyl-dimethyl-silanyl)-amino]-7-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4<i>H</i>-benzo[1,4]thiazin-3-one

Synonyms:8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

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Chemical Property of 8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

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Technology Process of 8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

There total 21 articles about 8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 171013-66-4
tert-Butyl-{2-[(4S,5S,6R)-6-((Z)-3-iodo-1-methyl-propenyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-ethoxy}-dimethyl-silane

: 251089-55-1
8-benzenesulfonylmethyl-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

: 286372-29-0
8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

Guidance literature:: 8-benzenesulfonylmethyl-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

tert-Butyl-{2-[(4S,5S,6R)-6-((Z)-3-iodo-1-methyl-propenyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-ethoxy}-dimethyl-silane; In tetrahydrofuran; at -78 ℃; for 1.5h; Further stages.;
DOI:10.1021/jo991958j

Reference yield:

: 178747-79-0
methyl 2-fluoro-6-methoxybenzoate

: 286372-29-0
8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 95 percent / NO₂BF₄ / tetrahydrothiophene 1,1-dioxide / 15 h / 50 °C

2.1: LiOH / dimethylformamide / 3 h

2.2: 90 percent / dimethylformamide / 3 h / 20 °C

3.1: 35 percent / SnCl₂; aq. HCl / methanol / 14 h / Heating

4.1: 95 percent / aq. K₂CO₃ / acetone / 4 h

5.1: 35 percent / LiBH₄ / tetrahydrofuran / 0 °C

6.1: Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 6.5 h

7.1: 0.90 g / NaI / dimethylformamide / 13 h / 60 °C

8.1: 85 percent / BBr₃ / CH₂Cl₂ / 12 h / 20 °C

9.1: 60 percent / Et₃N / dimethylformamide / 2 h

10.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.08 h / -78 °C

10.2: 50 percent / tetrahydrofuran / 1.5 h / -78 °C

With hydrogenchloride; dmap; lithium hydroxide; lithium borohydride; nitronium tetrafluoborate; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; triethylamine; sodium iodide; tin(ll) chloride; In tetrahydrofuran; sulfolane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 1.1: Nitration / 2.1: deprotonation / 2.2: Substitution / 3.1: Reduction / 4.1: Substitution / 5.1: Reduction / 6.1: Tosylation / 7.1: Substitution / 8.1: Substitution / 9.1: silylation / 10.1: deprotonation / 10.2: Alkylation;
DOI:10.1021/jo991958j

Reference yield:

: 251089-58-4
2-fluoro-6-methoxy-3,5-dinitro-benzoic acid methyl ester

: 286372-29-0
8-(1-benzenesulfonyl-4-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-6-[(tert-butyl-dimethyl-silanyl)-amino]-7-(tert-butyl-dimethyl-silanyloxy)-4H-benzo[1,4]thiazin-3-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: LiOH / dimethylformamide / 3 h

1.2: 90 percent / dimethylformamide / 3 h / 20 °C

2.1: 35 percent / SnCl₂; aq. HCl / methanol / 14 h / Heating

3.1: 95 percent / aq. K₂CO₃ / acetone / 4 h

4.1: 35 percent / LiBH₄ / tetrahydrofuran / 0 °C

5.1: Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 6.5 h

6.1: 0.90 g / NaI / dimethylformamide / 13 h / 60 °C

7.1: 85 percent / BBr₃ / CH₂Cl₂ / 12 h / 20 °C

8.1: 60 percent / Et₃N / dimethylformamide / 2 h

9.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.08 h / -78 °C

9.2: 50 percent / tetrahydrofuran / 1.5 h / -78 °C

With hydrogenchloride; dmap; lithium hydroxide; lithium borohydride; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; triethylamine; sodium iodide; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 1.1: deprotonation / 1.2: Substitution / 2.1: Reduction / 3.1: Substitution / 4.1: Reduction / 5.1: Tosylation / 6.1: Substitution / 7.1: Substitution / 8.1: silylation / 9.1: deprotonation / 9.2: Alkylation;
DOI:10.1021/jo991958j