(S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one

Base Information

• Chemical Name: (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one
• CAS No.: 1373333-25-5
• Molecular Formula: C₂₁H₂₃NO₅
• Molecular Weight: 369.417
• Mol file: 1373333-25-5.mol

Synonyms:(S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one

Chemical Property of (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one

There total 2 articles about (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-methoxycinnamic acid (2107-70-2) + (S)-4-Benzyl-2-oxazolidinone (90719-32-7) → (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one (1373333-25-5)

Guidance literature:

With pivaloyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; at -20 - 20 ℃; for 2h;

Reference yield:

3-(3,4-dimethoxy-phenyl)-propionyl chloride (51842-87-6) + (S)-4-Benzyl-2-oxazolidinone (90719-32-7) → (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one (1373333-25-5)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 25h; optical yield given as %ee;

DOI:10.1021/jo300380z

Reference yield: 92.5%

bromoacetic acid tert-butyl ester (5292-43-3) + (S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one (1373333-25-5) → C27H33NO7

Guidance literature:

(S)-4-benzyl-3-(3-(3,4-dimethoxyphenyl)propanoyl)-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -78 ℃; for 2h;

upstream raw materials:

3-(3,4-dimethoxy-phenyl)-propionyl chloride

(S)-4-Benzyl-2-oxazolidinone

3,4-methoxycinnamic acid

Downstream raw materials:

C₁₃H₁₉NO₃

(S)-2-(3,4-dimethoxybenzyl)pent-4-enoic acid

(S)-2-benzyl-3-(3,4-dimethoxyphenyl)propanoic acid

(S)-4-benzyl-7,8-dimethoxy-2-propyl-4,5-dihydro-1H-benzo-[c]azepin-3(2H)-one