1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester

Base Information

• Chemical Name: 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester
• CAS No.: 73442-84-9
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453
• Mol file: 73442-84-9.mol

Synonyms:1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester

Chemical Property of 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester

There total 3 articles about 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-[2-(2-Benzyloxycarbonylamino-ethyl)-4-isopropyl-5-oxo-2,5-dihydro-oxazol-2-yl]-propionic acid ethyl ester (73442-74-7) → 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester (73442-84-9)

Guidance literature:

at 180 ℃; for 0.5h;

Reference yield:

[2-(4-Isopropyl-5-oxo-4,5-dihydro-oxazol-2-yl)-ethyl]-carbamic acid benzyl ester (73442-65-6) → 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester (73442-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / 48 h / 50 °C

2: 93 percent / 0.5 h / 180 °C

With triethylamine;

Reference yield:

2-(3-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyric acid (61058-48-8) → 1-Benzyloxycarbonyl-2-isopropyl-1,2,5,6-tetrahydro-4-pyrimidinpropionsaeure-ethylester (73442-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Ac₂O / 0.5 h / 80 - 90 °C

2: Et₃N / 48 h / 50 °C

3: 93 percent / 0.5 h / 180 °C

With acetic anhydride; triethylamine;

upstream raw materials:

3-[2-(2-Benzyloxycarbonylamino-ethyl)-4-isopropyl-5-oxo-2,5-dihydro-oxazol-2-yl]-propionic acid ethyl ester

[2-(4-Isopropyl-5-oxo-4,5-dihydro-oxazol-2-yl)-ethyl]-carbamic acid benzyl ester

2-(3-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyric acid

Downstream raw materials:

N-Benzyloxycarbonyl-6-amino-4-oxohexansaeure-ethylester